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Clinical trial results for Calistoga Pharmaceuticals’ CAL-101

Calistoga Pharmaceuticals, Inc., announced interim results from the ongoing Phase 1 trial evaluating CAL-101, a PI3K inhibitor, showing promising clinical responses in patients with relapsed or refractory chronic lymphocytic leukemia (CLL). At this interim assessment, 29 percent of CLL patients treated in the cohort expansion dose levels had partial responses observed after 28 days of therapy (1 cycle) and 94 percent have achieved evidence of biologic activity with a greater than 50 percent decrease in Read More >

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Trubion reports positive data from Phase 2B TRU-015 study

Trubion Pharmaceuticals, Inc. (Nasdaq: TRBN) announced favorable safety and efficacy data following administration of a second course (R2) of re-treatment with 800 mg of TRU-015 for rheumatoid arthritis (RA). These data are the latest results from the ongoing open-label re-treatment portion of the Phase 2b (15002) RA study of TRU-015. Pfizer Inc. and Trubion are collaborating on the development of TRU-015 for the treatment of autoimmune and inflammatory diseases, including RA. Trubion’s President and CEO, Read More >

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Rexahn reports Phase IIa data for Serdaxin

Rexahn Pharmaceuticals, Inc. (NYSE Amex: RNN) announced top-line results from a Phase IIa clinical study of SerdaxinTM, its major depressive disorder (MDD) drug candidate. The randomized, double blind, placebo controlled and dose ranging study enrolled 77 patients and was conducted at multiple U.S. sites to assess Serdaxin’s safety and preliminary efficacy. The study showed that patients ages 18-65 with MDD exhibited clinically meaningful improvement over baseline in symptoms of depression as measured by the Montgomery-Asberg Read More >

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Endocyte announces close of $26 million equity financing

Endocyte, Inc., completed a $26 million extension of its Series C financing. This round included participation from all existing institutional investors including Sanderling Ventures, Burrill & Company, American Bailey Ventures, Blue Chip Venture Company, and Triathlon Medical Ventures. Clarian Health Ventures also participated as a new investor.

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Targacept reports positive Phase 2b trial results for depression treatment

Targacept, Inc. (NASDAQ: TRGT) presented data from its Phase 2b clinical trial of TC-5214 as an augmentation (add-on) treatment in subjects with major depressive disorder who did not respond adequately to first-line treatment with the representative SSRI citalopram hydrobromide.  In the trial, the add-on TC-5214 arm (TC-5214 + citalopram) outperformed the add-on placebo arm (placebo + citalopram) on the primary outcome measure, the Hamilton Rating Scale for Depression-17, or HAM-D, and all of the secondary Read More >

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