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Reaction to the $1,000 Genome

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System promises to sequence tens of thousands of human whole genomes a year in a single laboratory. What do the first customers think? Life science technology company Illumina recently launched a sequencing platform that it claims will enable the $1,000 genome. The HiSeq X™ Ten Sequencing System comprises 10 ultra-high-throughput sequencers which together can sequence more than 18,000 genomes per year, making human whole-genome sequencing more affordable and accessible than ever before. The system builds Read More >

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Convention Attendees Make the Call on Expanded Access

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The BIO International Convention kicked off Monday with an interactive session organized by the BIO Board Standing Committee on Bioethics: The Bioethics of Drug Development—You Make the Call. Attendees engaged in a real-time polling exercise addressing the many difficult issues related to expanded access using a mock case study of a company – iCures – dealing with an expanded access request. Moderator Steve Usdin, Senior Editor, BioCentury, led the panel through challenging issues in drug Read More >

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Seek and Destroy

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Ubiquibodies combine the specificity of antibodies with the destruction signal of ubiquitinization. Stand by for targeted destruction of disease-causing proteins in the cell Proteins in a cell that are aged or otherwise damaged are recycled via the ubiquitin-proteasome pathway (UPP). The doomed protein is first tagged with a protein called ubiquitin, which acts like a molecular sign reading “destroy me”, and then broken down by the proteasome, which is the cell’s recycling center. This catabolism Read More >

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The Journey from the Bench to Bedside

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A partnership between a leading academic research center and a biologics company is aiming to develop new therapeutic opportunities Translational research enables therapies get to where they need to be – to the patient. The process is characterized by collaborative activity between university and company scientists. One recent example is the announcement of a three-year collaboration between MedImmune, the global biologics research and development arm of AstraZeneca, and the Clinical and Translational Science Institute (CTSI) Read More >

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Expand Investment in Basic Research Needed to Advance Medical Progress

Michael Coburn

In 2007, the Napier and Lane families struggled to find answers to their daughters’ developmental problems, which included impaired communication and socialization skills. Both of the girls had a disorder so rare that it subsequently became identified only by the name of the small fragment of chromosome 16 that was missing, namely “16p11.2 deletion syndrome.” Dan Pinkel and Joe Gray, researchers at the University of California, San Francisco developed microarray comparative genomic hybridization, a technology Read More >

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