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Precision Drugs for Bad Bugs

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Awareness is high that antibiotic resistance is a critical problem, but many still don’t appreciate the role played by antibiotics themselves in accelerating this problem’s spread. Single antibiotics capable of killing multiple bacterial species – a class of drugs termed “broad spectrum” – have long been seen as a panacea and a cure for all bacterial infections. Today, essentially all marketed antibiotics kill multiple species of bacteria. Unfortunately bacteria that become resistant to a particular Read More >

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Reaction to the $1,000 Genome

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System promises to sequence tens of thousands of human whole genomes a year in a single laboratory. What do the first customers think? Life science technology company Illumina recently launched a sequencing platform that it claims will enable the $1,000 genome. The HiSeq X™ Ten Sequencing System comprises 10 ultra-high-throughput sequencers which together can sequence more than 18,000 genomes per year, making human whole-genome sequencing more affordable and accessible than ever before. The system builds Read More >

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Convention Attendees Make the Call on Expanded Access

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The BIO International Convention kicked off Monday with an interactive session organized by the BIO Board Standing Committee on Bioethics: The Bioethics of Drug Development—You Make the Call. Attendees engaged in a real-time polling exercise addressing the many difficult issues related to expanded access using a mock case study of a company – iCures – dealing with an expanded access request. Moderator Steve Usdin, Senior Editor, BioCentury, led the panel through challenging issues in drug Read More >

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Seek and Destroy

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Ubiquibodies combine the specificity of antibodies with the destruction signal of ubiquitinization. Stand by for targeted destruction of disease-causing proteins in the cell Proteins in a cell that are aged or otherwise damaged are recycled via the ubiquitin-proteasome pathway (UPP). The doomed protein is first tagged with a protein called ubiquitin, which acts like a molecular sign reading “destroy me”, and then broken down by the proteasome, which is the cell’s recycling center. This catabolism Read More >

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The Journey from the Bench to Bedside

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A partnership between a leading academic research center and a biologics company is aiming to develop new therapeutic opportunities Translational research enables therapies get to where they need to be – to the patient. The process is characterized by collaborative activity between university and company scientists. One recent example is the announcement of a three-year collaboration between MedImmune, the global biologics research and development arm of AstraZeneca, and the Clinical and Translational Science Institute (CTSI) Read More >

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