Tag Archives: BIO International Convention

Seeing is Believing

brain-scan

PET and MRI imaging helps companies to make go/no go decisions earlier Attrition or failure of new drug programs is a major source of concern, with failure rates ranging from 75 percent in anti-infectives to 92 percent in CNS according to DiMasi’s 2010 study (Clin. Pharmacol. Ther. 87, 272-277). Molecular imaging – both Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) can help improve these dismal statistics. Given the immense costs involved in the Read More >

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A Better Way to Make Unnatural Amino Acids Discovered by Yu

Make Unnatural Amino Acids

Certain amino acids that are not found in nature are highly sought after by pharmaceutical manufacturers. These “unnatural” amino acids have traditionally been very difficult to synthesize, so a new and improved technique for doing so is attracting a lot of attention. Amino acids are among the most basic components of living things. Long chains of them, translated from DNA, fold up to become proteins, some smaller groupings of amino acids form hormones, and a Read More >

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New Target for Alzheimer’s Disease

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Biotechnologists have developed a drug candidate that blocks production of diseasecausing neurotoxins in mouse models Reducing the concentration of cathepsin B using an enzyme inhibitor prevents the creation of the neurotoxic peptide, pyroglutamate-AB (pGlu-AB), which has been linked to the development of Alzheimer’s disease (AD). The candidate inhibitor drug, a cysteine protease inhibitor named E64d, was developed by scientists from the University of California, San Diego School of Medicine, the Medical University of South Carolina and Read More >

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Making the Case for Personalized Medicine

Personalized-Medicine

Personalized medicine is the customization of healthcare. Already, a suite of molecular approaches is being used to tailor certain medical decisions, practice and products to the individual patient. For example, melanoma, leukemia and metastatic lung, breast and brain cancers can be routinely “molecularly diagnosed” and treated with medicines that target the specific genetic mutations. These represent a remarkable improvement over trial-and-error medicine. Other diagnostic tests use the patient’s DNA sequence to determine drug-metabolizing capabilities. This Read More >

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21st Century Cures: Accelerating the Discovery-Development-Delivery Cycle

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How can we give patients faster access to innovative treatments and cures? That’s the question the House Energy and Commerce Committee is asking our nation’s foremost medical experts and innovators through white papers, hearings, and roundtables in an initiative we call 21st Century Cures. Our collaboration includes everyone from the National Institutes of Health and the Food and Drug Administration to patients, researchers, health entrepreneurs, and other thought leaders. Through 21st Century Cures, our goal Read More >

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